{"id":1143,"date":"2019-07-01T16:56:22","date_gmt":"2019-07-01T14:56:22","guid":{"rendered":"https:\/\/sonofirst-trial.eu\/publications_science\/safety-and-feasibility-of-repeated-and-transient-blood-brain-barrier-disruption-by-pulsed-ultrasound-in-patients-with-recurrent-glioblastoma\/"},"modified":"2019-07-01T16:56:22","modified_gmt":"2019-07-01T14:56:22","slug":"safety-and-feasibility-of-repeated-and-transient-blood-brain-barrier-disruption-by-pulsed-ultrasound-in-patients-with-recurrent-glioblastoma","status":"publish","type":"publications_science","link":"https:\/\/sonofirst-trial.eu\/en\/publications_science\/safety-and-feasibility-of-repeated-and-transient-blood-brain-barrier-disruption-by-pulsed-ultrasound-in-patients-with-recurrent-glioblastoma\/","title":{"rendered":"Safety and Feasibility of Repeated and Transient Blood\u2013Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma."},"content":{"rendered":"<p><strong>Ahmed Idbaih, Michael Canney, Lisa Belin, Carole Desseaux, Alexandre Vignot, Guillaume Bouchoux, Nicolas Asquier, Bruno Law-Ye, Delphine Leclercq, Anne Bissery, Yann De Rycke, Clementine Trosch, Laurent Capelle, Marc Sanson, Khe Hoang-Xuan, Caroline Dehais, Caroline Houillier, Florence Laigle-Donadey, Bertrand Mathon, Arthur Andre\u0019, Cyril Lafon, Jean-Yves Chapelon, Jean-Yves Delattre, and Alexandre Carpentier.<\/strong><br \/>\n<strong>DOI: 10.1158\/1078-0432. CCR-18-3643<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30890548\/\"><strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/30890548\/<\/strong><\/a><\/p>\n<h2>Abstract<\/h2>\n<h3>Purpose:<\/h3>\n<p>The blood-brain barrier (BBB) limits the efficacy of drug therapies for glioblastoma (GBM). Preclinical data indicate that low-intensity pulsed ultrasound (LIPU) can transiently disrupt the BBB and increase intracerebral drug concentrations.<\/p>\n<h3>Patients and methods:<\/h3>\n<p>A first-in-man, single-arm, single-center trial (NCT02253212) was initiated to investigate the transient disruption of the BBB in patients with recurrent GBM. Patients were implanted with a 1-MHz, 11.5-mm diameter cranial ultrasound device (SonoCloud-1, CarThera). The device was activated monthly to transiently disrupt the BBB before intravenous carboplatin chemotherapy.<\/p>\n<h3>Results:<\/h3>\n<p>Between 2014 and 2016, 21 patients were registered for the study and implanted with the SonoCloud-1; 19 patients received at least one sonication. In 65 ultrasound sessions, BBB disruption was visible on T1w MRI for 52 sonications. Treatment-related adverse events observed were transient and manageable: a transient edema at H1 and at D15. No carboplatin-related neurotoxicity was observed. Patients with no or poor BBB disruption (n = 8) visible on MRI had a median progression-free survival (PFS) of 2.73 months, and a median overall survival (OS) of 8.64 months. Patients with clear BBB disruption (n = 11) had a median PFS of 4.11 months, and a median OS of 12.94 months.<\/p>\n<h2>Conclusions:<\/h2>\n<p>SonoCloud-1 treatments were well tolerated and may increase the effectiveness of systemic drug therapies, such as carboplatin, in the brain without inducing neurotoxicity.See related commentary by Sonabend and Stupp, p. 3750.<\/p>\n<p>\u00a92019 American Association for Cancer Research.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ahmed Idbaih, Michael Canney, Lisa Belin, Carole Desseaux, Alexandre Vignot, Guillaume Bouchoux, Nicolas Asquier, Bruno Law-Ye, Delphine Leclercq, Anne Bissery, [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","projet_type":[6],"keywords":[],"class_list":["post-1143","publications_science","type-publications_science","status-publish","hentry","projet_type-sonofirst"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Safety and Feasibility of Repeated and Transient Blood\u2013Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma. - 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